Players are reporting that game crashing when they trying to run the Destiny 2. There is a temporary solution to this problem. You should also check out the “How to Fix Crashing while Playing the Destiny 2“
How to Fix the Destiny 2 Crashing on Launch Issue
1) Problem Reading Game Content
In Destiny 2, if you are experiencing the “Problem reading game content” error at launch, you should check out the “Problem reading game content guide“.
2) Previous Problem
Hotfix: Fixed an issue where having more than 300 friends would cause the game to crash. So you don’t have to delete your friends anymore.
This issue is related to having too many friends on Steam friends list. You have to have under 300 friends on Steam friends list so you should delete or block your friends.
By the way, don’t try to unblock your friends when you are playing Destiny 2, the game will crash again.