Does the mouse not work on the GTA: San Andreas? Can't you move and click anything? Here is the solution.
How to Fix Mouse Issue in GTA:SA?
- Launch the GTA:SA
- Open the Task Manager
- Go to the Details tab.
- Right-click on the gta_sa.exe
- Click on the Set affinity
- Uncheck all cores. Just select two cores. For example, check CPU 0 and CPU 1
- Click on the OK button.
- If the game is on Steam. Launch the game.
- Go into steam overlay
- Return to game now
You can use the Silent Patch: https://steamcommunity.com/app/12120/discussions/0/34096318964479523/
I hope it helped you to resolve this strange problem.